Abordagens clinicas e aspectos patológicos relacionados relacionados ao hemangiossarcoma cardíaco em cães: revisão de literatura

Abstract

Hemangiosarcoma is characterized by being a malignant neoplasm originating from the mesenchymal tissue of endothelial cells, being an important measurement in dogs, as it manifests itself in several organs, including the heart, in a primary or secondary way (through metastasis). In the heart, this disease can be observed in the walls of the right atrium, and, eventually, in the right ventricle. Cardiac hemangiosarcoma may have clinical signs, mainly cardiac tamponade, right heart failure, pericardial effusion and cardiac arrhythmia, however, such signs may vary according to the size of the tumor. In relation to etiopathogenesis and oncogenesis, they have not yet been well clarified, where their origin indicates that they are from bone marrow precursor endothelial cells, and it is also worth highlighting the association with hereditary predisposition. Furthermore, its diagnosis is difficult to conclude, as the changes are not well visualized in exams, such as radiography, laboratory and cytological analyzes of the pericardial fluid, due to the difficult cell differentiation in the effusion. Therefore, definitive diagnosis includes thoracotomy or thoracoscopy, together with biopsy. Regarding treatment, surgical or chemotherapy methods can be taken, such as performing exploratory thoracotomy to resect the tumor mass, respecting safety margins. While chemotherapy includes the interaction of vincristine, doxorubicin and cyclophosphamide, it is more advisable to administer it immediately after the surgical procedure. Therefore, the aim of this work was to highlight and analyze clinical and pathological aspects of this disease, taking into account literary data related to cardiac hemangiosarcoma in dogs.