O efeito da própolis e da membrana amniótica no tratamento de queimaduras provocadas em ratos: um estudo macro e microscópico

Abstract

The present work aimed to study macro and microscopically the dermal and epidermal response in the regenerative or healing repair process of rats treated daily with different and alternative local dressings. After anesthesia, a burn with a plate heated to 130 ° C for five seconds in 29 rats that were divided into three groups, being a control group treated with sterile saline (n = 9), group treated with propolis ointment (n = 10) and group treated with amniotic membrane (n = 10). The animals were euthanized at seven, 14 and 21 days of treatment. Macro and microscopically on the seventh day after injury, animals treated with propolis already showed significant acceleration of the healing process. The granulation tissue was evident and chronologically more advanced than in the control group, where the granulation tissue was more evident on the 21st day after burning, while the amnion-treated group, despite not accelerating the healing process, did not show inflammatory cells. since the first days of application. Both treatments studied were effective in treating burns compared to the control group. The 5% propolis ointment accelerated the local tissue repair process and therefore anticipated healing in the initial period macroscopically. The amniotic membrane stimulated tissue cell regeneration at the injured site and inhibited the inflammatory reaction on all days following the injuries.